HMOX1 and familial pancreatic carcinoma: The genes in this network were around TNF, HMOX1 and three perilipin family members, PLIN2, PLIN3 and PLIN4. TNF has been reported to modulate pancreatic cancer cell growth by affecting tumor-infiltrating macrophages, and HMOX1 protects against oxidative stress and modulates inflammation and angiogenesis.