CYLD and skin neoplasm: Another protein, CYLD which deubiqitinates TRAF6 (Jono et al. 2004; Kovalenko et al. 2003; Yoshida et al. 2005), and is negatively regulated by specific TNF receptors (Trompouki et al. 2003), might play a role of a silencer of EDAR signaling, since mutations in CYLD predispose not only to skin tumors (cylidromatosis) (Saggar et al. 2008), but also to the development of tumors of eccrine sweat glands and hair follicles (Brummelkamp et al. 2003; Trompouki et al. 2003).