Although the Eda-A2/Xedar pathway has not been associated with the mouse variant of HED, it has been demonstrated that Xedar activates the NF-κB pathway in a ligand-dependent fashion with the mediation of Traf6 and the kinases of the IKK complex (Naito et al. 2002). This evidence concerns the gene EDA and hypohidrotic ectodermal dysplasia.