FGFR4 and primary biliary cholangitis: In PBC cirrhotic livers FGF19 expression was significantly increased in comparison to controls both at mRNA (69-fold, p < 0.0001, Fig. 2A) and protein levels (9-fold, p < 0.0001, Fig. 2C) which was accompanied by enhanced expression of FGFR4 protein (3.5 fold, p = 0.007, Fig. 2D).