In the present study, we have further assessed CNVR 13q12.11 because (i) CNV gain at locus 13q is one of the highest differentially expressed CNVs in the hepatocellular carcinoma (HCC) genome10; (ii) it contains exportin-4 (XPO4), a tumor suppressor gene involved in the pathogenesis of HCC11; and (iii) a previous report has shown that XPO4 is known to be expressed in both the liver and peripheral blood12. The gene discussed is XPO4; the disease is hepatocellular carcinoma.