Mutations in genes now known to cause ALS include SOD11, FUS/TLS2, 3, VAPB4, TARDBP5, 6, OPTN7, VCP8, SQSTM19, UBQLN210, PFN111, MATR312 and hexanucleotide expansions in C9ORF7213. The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.