SEMA3E and systemic sclerosis: In SSc patients with early NVC pattern, Sema3E levels were significantly increased (median 1.17 ng/ml, range 0.65−1.35 ng/ml) compared with active (median 0.65 ng/ml, range 0.00−1.71 ng/ml) and late (median 0.55 ng/ml, range 0.00−1.35 ng/ml) NVC patterns (both p <0.05) (Fig. 2b).