In addition, Sema3E levels were significantly increased in SSc patients without DUs (median 1.03 ng/ml, range 0.00−1.71 ng/ml) compared with patients with DUs (median 0.57 ng/ml, range 0.00−1.20 ng/ml) (p = 0.018) (Fig. 2c). This evidence concerns the gene SEMA3E and systemic sclerosis.