CRP and neoplasm: Elevated CRP levels (CRP ≥5.0 mg/L) were found to be associated with the skin invasion (P = 0.009), bone invasion (P < 0.001), tumor depth (≥10 vs. <10 mm, P < 0.001), pathological tumor status (P < 0.001), and pathologic nodal metastasis (P = 0.049) (Table 2).