When the patients were divided into four groups according to the preoperative higher or lower CYFRA 21-1 and CRP levels, a close association was observed between a coexistence of higher CYFRA 21-1 (≥3.3 ng/mL) and higher CRP (≥5.0 mg/L) status and pathological tumor status (χ2 trend test P < 0.001), pathologic nodal metastasis (χ2 trend test P = 0.012), tumor stage (P = 0.009), bone invasion (P = 0.001), skin invasion (P = 0.006), and tumor depth (≥10 vs. <10 mm, P < 0.001) (Table 3). Here, CRP is linked to neoplasm.