Neutrophils are hypothesized to contribute to tumor progression and aggressive biology through the production of cytokines (such as such as tumor necrosis factor, interleukin (IL)-1, and IL-6), chemokines and granule proteins, which are thought to promote tumor proliferation and angiogenesis, and increase its metastatic potential [18, 39, 40]. The gene discussed is TNF; the disease is neoplasm.