IGHE and asthma: Interestingly, this study also found that the methylation levels in isolated eosinophils differed among asthmatics with high total IgE, asthmatics with low total IgE, and controls, suggesting that eosinophils from persons with allergic hypersensitivity or asthma may have different epigenetic profiles compared to eosinophils from non-allergic individuals [52].