Functional annotation of the 10 genes (ZFPM1, PRG2, KIAA0494, EPX, ATL3, LSM14B, COPA, ZNF862, ASCC1, and PVALB) associated with the 13 replicated CpG sites (Table 6) revealed three statistically significant annotations: polymorphism, eosinophil, and asthma. This evidence concerns the gene PVALB and asthma.