LGALS2 and major depressive disorder: Gal2-deficient mice have anxiogenic-like and depression-like phenotypes (Bailey et al., 2007; Lu et al., 2008), and compounds with a marked preference for binding Gal2 over Gal1 have anticonvulsive and anti-nociceptive activities (Metcalf et al., 2015; Robertson et al., 2010).