In our study, each stimulating agent investigated (LPS, RCA and HDE) significantly increased (in comparison to unstimulated cells) the expression level of the HIF1A gene and NFKB2 encoding a subunit of the NF-κB transcription factor, which activates cellular signalling pathways via dynamic modulation of cytokines, chemokines and other signalling molecules, and is an important signalling element of the immune response in asthma [98]. The gene discussed is HIF1A; the disease is asthma.