In addition, we found a significant association between uPAR positive myofibroblasts and macrophages at the invasive front and higher tumour grade (p = 0.0013, p = 0.0001), uPAR positive myofibroblasts at the invasive front and lymph node metastasis (p = 0.021), uPAR positive myofibroblasts and macrophages in tumour core and lymph vascular invasion (p = 0.014, p = 0.040), as well as between uPAR positive myofibroblasts and macrophages at the invasive front and concomitant CIS (p = 0.026, p = 0.015). The gene discussed is PLAUR; the disease is neoplasm.