The gene category“NOD-like receptor signaling pathway”, which consists of NOD1, has been showed that NOD1/CARD4 and NOD2/CARD15 gene polymorphisms may be associated with altered risk of gastric[22], colorectal[23], lung[24], laryngeal[25], gallbladder[26], pancreatic[27], small bowel, kidney[28], urinary bladder cancer[29], skin cancer, lymphoma[30] and leukemia[31]. Here, NOD2 is linked to skin neoplasm.