Interestingly, low concentrations of testosterone and sex hormone-binding globulin (SHBG) in men [34] and postmenopausal women (where there is low estrogen levels) [35] have been found to be associated with increased metabolic abnormalities such as visceral obesity, insulin resistance, hyperinsulinemia, and dyslipidemia. This evidence concerns the gene SHBG and Hyperinsulinemia.