Figure 4 presents the result of a two-way cluster analysis of Pearson's correlation coefficients between the food and brain proteins or peptides where we see that IgG, IgA, and IgM isotypes are clustered together with high correlations among the food and brain proteins or peptides in each isotype. While there was a correlation between the reactivities of the MS patients' sera to neural cell antigens and plant aquaporins, the differences in IgM antibody reactivity between the two groups was the most significant (Figure 4). The gene discussed is CD40LG; the disease is myeloid sarcoma.