Although an association between plant antigens and autoimmune diseases has been previously suggested for celiac disease, lupus, scleroderma, type I diabetes, and MS [40–44], there is need for further evaluation of the role of plant proteins in the generation of cross-reactive antibodies against human AQP4, S100B, MOG, and MBP and the consequent development of RRMS and other neuroimmune disorders. This evidence concerns the gene S100B and scleroderma.