Firstly, patients are usually symptomatic when blood glucose levels fall below 3 mmol/L unless they have had frequent hypoglycaemic events in the past or are on beta-blocker therapy, rendering them “hypoglycaemia unaware.” Secondly, the management of hypoglycaemia is much simpler in the initial stages with oral or intravenous glucose formulations or intramuscular glucagon, with an almost immediate rise in blood glucose levels. This evidence concerns the gene GCG and Hypoglycemia.