In a recent study using a pituitary tumor model including GH-secreting pituitary cells, through upregulation of the PI3K/Akt pathway, as well as mitogen-activated protein kinase pathways, octreotide increased both transcription of the mixed lineage leukemia (MLL) gene and levels of p27(Kip1), a protein that controls G1 cell cycle progression [24]. This evidence concerns the gene GH1 and pituitary tumor.