In the present study we tested the genetic association of SNPs in ADIPOQ with obesity indexes (BMI, body fat content, waist (WC) and hip circumferences (HC)) and serum adiponectin levels in African Americans from the Jackson Heart Study (JHS) with adjustment for population structure using a dense panel of ancestry informative markers (AIMs). This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.