RPS6KB2 and chronic myelogenous leukemia, BCR-ABL1 positive: We isolated the most primitive LT stem cells (CD150+CD48−CD135−KLS+ cells)8, short-term (ST) stem cells (CD150−CD48−CD135− KLS+ cells) and KLS− progenitor cells (Supplementary Fig. 3) from healthy littermate control and CML-affected mice and performed gene expression profiling using next-generation RNA sequencing.