It should also be noted that, although we could not detect an obvious increase in amino acids in CML-KLS+ cells, including in branched-chain amino acids such as Leu (Fig. 1b; Supplementary Data 1), we cannot exclude the possibility that the downstream nutrient signalling induced by dipeptide uptake includes regulation of the mTORC1 pathway by the cell's amino-acid-sensing machinery46, 47, 48, 49, 50, 51. The gene discussed is RPS6KB2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.