Although we cannot exclude the possibility that there is a systemic increase in dipeptide species in the blood of tet-inducible CML-affected mice, we saw no obvious correlation between dipeptide levels in the rare population of CML-KLS+ cells and the vast majority of differentiated CML-Lin+ cells (Supplementary Fig. 2). The gene discussed is RPS6KB2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.