TCF7 interacts with multiple proteins and target genes (e.g. CD3E, β-catenin, TCF7L2, LEF-1, IL-17, IL-4, or Eomes) and is involved in several signal pathways (e.g. Wnt, FoxO1, Notch, or P21pathways) which are critical for lung diseases, especially the canonical Wnt/β-catenin pathway. The gene discussed is LEF1; the disease is lung disorder.