TCF7L2 and neoplasm: TCF7L2 binds to and transactivate the enhancer of TCF7 gene with the coactivator β-catenin and promotes TCF7 transcription, while TCF7 down-regulates TCF7L2 target genes and acts as a feedback repressor of β-catenin/TCF7L2 with a potential function of tumor suppressor [30].