A gradient of inflammatory cytokines released by Th2 cells particularly IL-4, IL-5 and IL-13 coordinates major pulmonary inflammatory responses, which involves development, migration, inflammatory cells activation, allergen-specific antibody production, goblet cell hyperplasia, increase in vascular permeability, and airway reactivity, all of which plays a central role in asthma pathogenesis, and pathology [4, 14, 38]. This evidence concerns the gene IL4 and asthma.