There was no gender difference in the frequency of TYK2 promoter variant, among patients with T1D (male, 13/113; 11.5%, female, 16/189; 8.5%; P = 0.39), and also T2D (male, 14/161; 8.7%, female, 13/153; 8.5%; P = 0.95). This evidence concerns the gene TYK2 and type 1 diabetes mellitus.