There was no statistical significance in the age at onset (P = 0.16), but has significantly increased frequency in anti-GAD antibody negative T1D (OR, 5.0; 95% CI, 1.9 to 13.2; P = 0.0005) (Supplementary Table 3), consistent with the observation of all T1D patients. The gene discussed is GAD1; the disease is type 1 diabetes mellitus.