TYK2 and type 1 diabetes mellitus: The frequency of the TYK2 promoter variant was significantly higher in patients with T1D (odds ratio (OR), 2.4; 95% confidence interval (CI), 1.2 to 4.6; P = 0.01), and also in patients with T2D (OR, 2.1; 95% CI, 1.1 to 4.1; P = 0.03), compared with healthy controls (Table 3).