Although PD-L1 positivity is correlated with response to pembrolizumab in patients with melanoma, given the responses seen in patients with PD-L1-negative tumors and the high prevalence of PD-L1 positivity, it is unlikely that PD-L1 will be used as a selection or predictive marker for anti-PD-1 or anti-PD-L1 agents in melanoma. The gene discussed is CD274; the disease is melanoma.