BRAF and metastatic melanoma: Based on the data obtained from the randomized cohort of 173 ipilimumab-refractory patients and supportive data from other KEYNOTE-001 melanoma cohorts, pembrolizumab 2 mg/kg Q3W is now FDA approved for the treatment of patients with unresectable or metastatic melanoma with disease progression following ipilimumab, and if BRAFV600mutation positive, a BRAF inhibitor.