AKT1 and obesity due to melanocortin 4 receptor deficiency: Studies in obesity-animal models (either induced by a high fat diet or genetically modified) showed an increase in TRB3 expression and in the TRB3/Akt association in the skeletal muscle tissue and the liver, with a consequent increase in blood glucose concentration, which later on led to the development of insulin resistance and DM2 [28, 29, 41].