It was found that more patients in the saxagliptin group are hospitalized due to HF (3.5 % vs. 2.8 %; HR, 1.27; 95 % CI, 1.07 to 1.51; P = 0.007) and this DPP-4 inhibitor did not provide any cardioprotective benefit [65, 66]. The gene discussed is DPP4; the disease is hydrops fetalis.