In a recent study investigating the role of the potent bone regulating Wnt/β-catenin pathway in Charcot arthropathy patients [30], we were able to show that 4 months after the start of offloading treatment, a significant increase occurred in systemic levels of the Wnt antagonist, dickkopf-1 (Dkk-1), and the Wnt agonist, Wnt-1, both being part of bone remodeling [31, 32]. This evidence concerns the gene WNT1 and neurogenic arthropathy.