The main features of IL-17E, besides eosinophilia, is to inhibit the production of pro-inflammatory cytokines, such as TNF-α and IL-17A, and at the same time shift immune responses towards the Th2 phenotype and thereby increase the production of anti-inflammatory cytokines, such as IL-4, Il-5 and IL-13 [28]. Here, TNF is linked to Increased total eosinophil count.