APP and pulmonary arterial hypertension: Some evidence for many other additional roles (modulators of angiogenesis; regulators of the number of monocytes and NK cells; in the brain, where they are involved in Amyloid Precursor Protein (APP) processing; in lungs, where they participate in the vascular remodeling processes linked to pulmonary hypertension, etc.)has been also obtained [18, 29, 30].