COMT and irritable bowel syndrome: Similarly, compared to the individuals who presented with a heterozygous or homozygous state of the minor A allele (i.e., had at least one minor A allele) for COMT rs174697, individuals who carried the homozygous major G allele (i.e., had both copies of the major G allele) had a higher likelihood of having IBS if they had an increasing emotional abuse score (OR: 1.52 [1.33–1.74] vs. 1.14 [0.92–1.42], p = 0.041) (Fig 2).