Based on our above findings, we determined brain structural changes correlated with: 1) ADRAβ2 SNP rs1042717 with and without taking sexual abuse score into account, 2) COMT SNP rs174697 with and without taking emotional abuse score into account, and 3) ADRA1D SNP rs1556832 in IBS. Here, ADRA1D is linked to irritable bowel syndrome.