NR1H3 and diabetes mellitus: To investigate the effect of glucose levels on LXR-mediated gene expression in macrophages, RAW cells stably expressing human LXRα (RAW WT) were maintained in diabetes relevant high glucose (25 mM D-glucose; 4.5 g/L D-glucose) or normal glucose (5.5 mM D-glucose; 1 g/L D-glucose supplemented with 3.5 g/L of L-glucose as an osmotic control) for two weeks.