While we show here that MAGL inhibition leads to substantial suppression of the fever response in both the peripheral LPS and central IL-1β fever models, we note that MAGL inhibitors do not completely suppress fever in these models, which contrasts with the full suppression observed with COX inhibitors [38,39], suggesting the existence of other pools of AA that may contribute to PGE2 production. This evidence concerns the gene IL1B and Fever.