The JAK/STAT pathway is known to be influenced by growth factors and cytokines other than leptin, and in a human lung adenocarcinoma cell line, dexamethasone has been shown to enhance interleukin-6 activation of JAK/STAT signalling without any direct effect on pSTAT3 (Ser727 or Tyr705) or STAT3 protein concentration [40]. The gene discussed is LEP; the disease is lung adenocarcinoma.