DHFR and colorectal cancer: Of these, we confirmed our ability to identified previously validated important targets that play key roles in colorectal cancer including thymidylate synthase (TS, TYMS), dihydrofolate reductase (DHFR) and denticleless (DTL), as well as novel targets such as histone H3F3B and DNA mismatch repair protein MutS homolog 6 (MSH6).