NCOA1 and breast cancer: Furthermore, the expression level of VEGFa mRNA, but not VEGFc mRNA, is increased more than 3 folds in NCOA1-overexpressing mammary tumors in Tg(MMTV-NCOA1) × Tg(MMTV-TVA/RCAS-PyMT) mice when compared with that in Ncoa1 WT mammary tumors in Tg(MMTV-TVA/RCAS-PyMT) mice (Figure 3c).