Together, these findings indicate that the angiogenic function of NCOA1 in breast tumor is mediated, in part, by serving as a transcriptional coactivator for both HIF1α and AP-1 mediated VEGFa expression, since the crucial role of VEGFa in both physiological and pathological angiogenesis has been extensively studied and well documented [26, 49]. This evidence concerns the gene FOS and breast neoplasm.