Furthermore, MVD is also significantly increased in NCOA1-overexpressing mammary tumors in Tg(MMTV-NCOA1) × Tg(MMTV-Neu) mice versus mammary tumors with normal Ncoa1 expression in Tg(MMTV-neu) mice at both week 2 and week 9 after the detection of palpable tumors (Figure 1a and 1b). This evidence concerns the gene NCOA1 and breast cancer.