Feedback loops that involve specific miRNAs and different components of the EGFR pathway also exist: miR-143 and miR-145 regulate the EGFR pathway genes KRAS, BRAF, and MEK2 [56,57], but EGFR signals down-regulated these tumor suppressor miRNAs in a murine model of colon cancer [69]. The gene discussed is EGFR; the disease is malignant colon neoplasm.