In a cross-sectional study of 126 adults evaluated on average 5.8 years after TBI, 57% were found to have GHD or GHI (GH insufficiency, defined as response to insulin-induced hypoglycemia between 3–10 ng/mL) associated with IGF-I SDS < −2.0 [24]. The gene discussed is INS; the disease is Hypoglycemia.