Finally, according to a recent genetic screen performed in Drosophila, both the wt- and mutant ALS-linked VAPB interact with TOR (target of rapamycin), the important regulator of cellular anabolic and catabolic functions, as well as potent repressor of autophagy, suggesting that P56S-VAPB could be involved in disturbances of several aspects of the proteostasis network [157]. The gene discussed is VAPB; the disease is amyotrophic lateral sclerosis.