Zuscik and colleagues have shown that treatment of articular chondrocytes with 5-azacytidine (5azaC), an anti-tumor agent that functions by blocking DNA methylation, resulted in a shift of regulatory dominance from maturation suppression via TGFβ signaling to maturation acceleration by BMP-2 signaling, which confirms that a shift in signaling dominance from TGFβ to BMP is sufficient to induce AC maturation [60]. The gene discussed is TGFB1; the disease is neoplasm.