The main genetic feature (90% APL cases) of this disease is chromosomal translocation t(15;17) (q22;q12) that generates the PML-RARα (promyelocytic leukemia-retinoic acid receptor α) fusion protein comprising parts of the PML and retinoic acid receptor α (RARα) genes [1,3]. This evidence concerns the gene PML and acute promyelocytic leukemia.