We showed that after BML-210 treatment, endoplasmin, calreticulin, 14-3-3 protein eta, and proliferating cell nuclear antigen were down-regulated, while a few proteins were up-regulated: chloride intracellular channel protein 1, lactoylglutathione lyase, etc. All these proteins are important in cancer cell proliferation and apoptosis. Here, CLIC1 is linked to cancer.