Specifically, cytokines like IL-1β and associated angiogenic modulators are reported to be a crucial component of brain and systemic degeneration processes in aging [90, 91] and in degenerative diseases [92, 93, 94], such as conversion from Mild Cognitive Impairment into Alzheimer's disease (for a review see [95]). The gene discussed is IL1B; the disease is neurodegenerative disease.