MYC and cancer: Analysis of the cell cycle data revealed that cells were unable to transit from G1 phase to S phase with increasing concentration of BTC f. The increase in concentration of BTC f triggered cell cycle arrest in SubG1 phase and subsequent apoptosis in cancer cells, probably by down-regulating c-MYC gene expression41, 42, 43 as suggested by qRT-PCR and Western blot analysis (Figs 5 and 6).