CUL3 and hypertensive disorder: While FHHt patients with CUL3, KLHL3 or WNK mutations present with the same disease, those with mutations in CUL3 display a more severe phenotype, evident in terms of both an earlier age-of-onset and the degree of hypertension and electrolyte disturbance reported (Boyden et al, 2012; Osawa et al, 2013; Tsuji et al, 2013).