In a complementary approach to modulate the impact of early expansion of Treg on parasite immunity, we made use of transgenic mouse models, in which diphtheria toxin receptor (DTR) and green fluorescent protein (GFP) are expressed under the Foxp3 promoter, in order to specifically deplete GFP+ Tregs at early time points in infection. This evidence concerns the gene FOXP3 and infection.