IL5 and parasitic infectious disease: CD25 is expressed at high levels by a subset of IL-5+ and IL-13+ ILC2 cells within the lung and mediastinal lymph node of naive mice.57 Interestingly, despite expanded ILC populations in IL-2C-treated mice, we noted that infected BALB/c mice had higher adult worm burdens and were more susceptible to parasite infection, arguing that ILC-derived cytokine production is insufficient to drive immunity.