IFNG and infection: Although such treatment effectively reduced antigen-specific IFN-γ production in the MLN (Figure 5i), it failed to restore resistance to infection and indeed further impaired parasite immunity, as Treg-depleted mice treated with anti-IFN-γ neutralizing Ab had significantly higher worm burden at day 28 postinfection, compared with Treg-depleted mice treated with an isotype control (Figure 5j).