Given the established role of dendritic cells in driving CD4+ T-cell activation and pro-inflammatory cytokine production, it is likely that Treg control of dendritic cell function underlies the subsequent control of parasite immunity.60 Near-complete depletion of Tregs in an independently constructed transgenic mouse, the BALB/c DEREG, at days 1, 3, and 5 following infection with H. polygyrus and in the BALB/c Foxp3.LuciDTR at days 4, 6, 8, and 10 postinfection (similar to Rausch et al.23) resulted in weight loss and a high severity score, so that experiments were discontinued. This evidence concerns the gene CD4 and infection.