IFN-γ production has been associated with increased epithelial cell proliferation and cecal crypt hyperplasia during T. muris infection65 and, moreover, with lymphedema in filariasis patients lacking Tregs,66 suggesting that pathology we observed in infected Treg-depleted BALB/c Foxp3.LuciDTR mice may also involve IFN-γ as well as other factors. This evidence concerns the gene IFNG and lymphedema.