In the present study, the antidepressant effects and a number of biomarkers of NVU functions including neurogenesis, fibrinolytic system and permeability of BBB were investigated in KJ-treated VD rats, such as BNDF, tropomyosin receptor kinase B (TrkB), tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), zona occludens protein-1 (ZO-1), occludin and claudin-5 [21–23]. Here, SERPINE1 is linked to sexually transmitted disease.