NGF and cartilage disease: Chondropathy is a hallmark of human OA,48 and cartilage changes are associated with pain severity.49 Clinical trials of NGF-blocking antibodies were put on hold due to the rare occurrence of RPOA.50 Small reductions in macroscopic and microscopic chondropathy scores observed following treatment with AR786 did not reach statistical significance and are unlikely to have made any major contribution to the observed reductions in pain behaviour.