On the other hand, analysis of established T2D loci in individuals of African ancestry revealed strong protective or risk effects on T2D for the minor alleles of low frequency nonsynonymous variants at SLC30A8, ARAP1, and GIPR (OR = 0.45–1.69, P < 1 × 10−4). The gene discussed is ARAP1; the disease is type 2 diabetes mellitus.