CHRNA7 and central nervous system disorder: Alpha7 nicotinic acetylcholine receptor (α7 nAChR) is a major cholinergic ligand-gated ion channel in the CNS, has been implicated in the modulation of the BBB integrity and pathogenesis of CNS disorders caused by microbial (e.g., HIV-1 virotoxins gp120) and non-microbial (e.g., METH and nicotine) factors [17–19].