Furthermore, we tested the consistency of the four suggested criteria for atypical tumor growth (i.e., Ki-67, invasiveness, number of mitosis and p53 levels) [7, 20–24, 6, 25], comparing a large cohort of typical pituitary adenomas (TPAs), APAs and pituitary carcinomas (PCAs). The gene discussed is TP53; the disease is pituitary adenocarcinoma.