Therefore, it can be said that the existence of an APA increases by a factor of 8.2 (p < 0.001) when an invasive growth pattern is present (Sensitivity 88 %, Specificity 53 %, Youden Index 0.41, Accuracy 64 %), by a factor of 5.2 (p < 0.001) per percentage point of Ki67 positive tumor cell nuclei, by a factor of 3.1 (p < 0.001) with each percentage point of p53 immunopositive nuclei and with a factor of 2.1 (p < 0.001) per every single mitosis in 10 HPF (Table 2; Fig. 2, a, b, c). The gene discussed is TP53; the disease is neoplasm.