IL6 and neoplasm: To identify this, we first analyzed the expression of miR-200c in in vitro generated MDSCs from different combinations of tumor-derived factors including GM-CSF alone, GM-CSF with IL-6, GM-CSF with TNFα and GM-CSF with IL-4 plus PGE2 according to the protocols previously described [16, 27, 28] (Fig 2A).