TRPV1 and obesity due to melanocortin 4 receptor deficiency: The observation, albeit in mice, that TRPV1 channels modulate gastric vagal afferent tension receptor mechanosensitivity and may mediate the reduction in gastric vagal afferent mechanosensitivity in response to HFD induced obesity suggests that modulation of TRPV1 channels may be an important target for the regulation of food intake.