The clinicopathological parameters of cases were also summarized in S1 Table, these including ER status (Positive, 621 cases; Negative, 237 cases), PR status (Positive, 562 cases; Negative, 292 cases), Her2 status (Positive, 234 cases; Negative, 621 cases), tumor size (≤ 2 cm, 382 cases; > 2 cm, 502 cases), lymph node status (Negative, 457 cases; Positive, 325 cases), clinical stage (0-I, 141 cases; II-IV, 654 cases), chemotherapy status (Yes, 822 cases; No, 144 cases) and endocrine therapy status (Yes, 233 cases; No, 850 cases). Here, ESR1 is linked to neoplasm.