Zhan Z et al. genotyped four potentially functional polymorphisms (rs13689, rs1801552, rs16260 and rs17690554) of the CDH1 gene in a case-control study of 387 gastric cancer cases and 392 controls, and they found no association of these four SNPs with overall gastric cancer risk, however, they revealed that rs16260 and rs17690554 were associated with the risk of diffuse gastric cancer in subgroup analysis [36]. This evidence concerns the gene CDH1 and gastric cancer.